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Neuroinvasiveness of YF/JE virusesa
| Virus | % Mortality (no. dead/no. tested)b | Strain |
|---|---|---|
| YF/JE-S | 0 (0/4) | ICR |
| YF/JE-N | 0 (0/13) | ICR |
| 20 (3/15) | C57BL/6 | |
| JE-N | 100 (12/12) | ICR |
| 100 (11/11) | C57BL/6 |
YF/JE-S, YF/JE-N, or JE-N was inoculated at 6 log10 PFU into 3-week-old mice by the intraperitoneal route.
For both ICR and C57BL/6 mice, the difference in mortality of YF/JE-N versus JE-N was significant (P < 0.005, by χ2 analysis of the proportion of survivors).
