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Schematic diagram of the BM microenvironment under normal conditions and following leukaemogenesis and treatment in AML (top right) and ALL (top left). After leukaemogenesis and treatment, the microenvironment is remodelled, pro-inflammatory and anti-angiogenic cytokines are produced resulting in the loss of vasculature in the endosteal and osteoblastic cells. Adapted from Refs 26, 27, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63.
