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. 2023 Aug 6;11(8):e007180. doi: 10.1136/jitc-2023-007180

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Differentiation and functional states of tumor antigen-specific CD8⁺ T cells. (A) Re-clustering of 140 antigen-specific T cells and UMAPs showing two different phenotypic clusters. The distribution of T-cell receptor against different tumor antigens (CTA or neoantigen) in each cluster is shown. (B) UMAPs of T-cell subset-defining genes. (C) Hierarchical clustering showing the log-normalized expression of T-cell subset-defining genes in individual T-cell clones (n=140). (D) The expression of T-cell subset-defining genes in each tumor antigen-specific T cell. CTA, cancer/testis antigens; UMAP, Uniform Manifold Approximation and Projection.