Table 1.

Examples of compounds in preclinical development

Inhibitor/compound series	Lead laboratory	Effective in animal models	Stage	References
Phosphatidylinositol 4-kinase	Novartis	Yes	Phase 1 human trials	15
Bumped kinase inhibitors	University of Washington	Yes	Preclinical candidate	26
Lysyl tRNA synthetase	DDU, University of Dundee	Yes	Late lead profiling	13
Benzoxaborole	Anacor, University of Vermont	Yes	Late lead profiling	29
SLU-2633/MMV665917	St. Louis University, University of Vermont	Yes	Late lead profiling	31
Phenylalanine tRNA synthetase	BROAD Institute, University of Vermont	Yes	Early lead profiling	16