FIG. 10.

SeV and SV5 block the induction of IFN-responsive gene mRNAs in MG-63 cells. MG-63 cells were infected with either SeV or SV5, and at 24 h p.i. the culture medium was supplemented with IFN for 4 h or left untreated. Twenty micrograms of total cellular RNA from cells was mapped with RNase protection probes corresponding to human IFN-β (5′IF), 6-16, IRF-1, or γ-actin mRNAs, and the protected fragments are indicated at the right.