Table 3. Univariable and multivariable analyses of preoperative prognostic factors for recurrence-free survival in all patients.
| Variables | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | ||
| Age, years | 1.102 (1.007–1.240) | 0.032 | 1.038 (0.934–1.199) | 0.526 | |
| Sex (male) | – | – | |||
| PS [1] | 5.094 (0.773–19.931) | 0.082 | |||
| FEV1% (<70%) | 1.056 (0.366–2.970) | 0.918 | |||
| CEA (>5.0 ng/mL) | 4.445 (1.326–13.546) | 0.018 | 3.248 (0.894–11.008) | 0.072 | |
| CYFRA (>3.5 ng/mL) | 3.175 (0.709–10.445) | 0.118 | |||
| SCC (>2.5 ng/mL) | 1.468 (0.400–4.422) | 0.531 | |||
| SUVmax | 1.039 (0.959–1.121) | 0.342 | |||
| VDT | 0.985 (0.974–0.993) | <0.001 | 0.989 (0.978–0.995) | <0.001 | |
CI, confidence interval; PS, performance status; FEV1, forced expiratory volume in the first second; CEA, carcinoembryonic antigen; CYFRA, cytokeratin 19 fragment; SCC, squamous cell carcinoma antigen; SUVmax, maximum standardized uptake value; VDT, tumor volume doubling time.