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. 2023 Jul 25;14:1202163. doi: 10.3389/fimmu.2023.1202163

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Copyright © 2023 Farley, Chengrui, Palmer, Liu, Kousa, Rouse, Major, Sweetman, Morys, Corsinotti, Nichols, Ure, McLay, Boulter, Chapman, Tomlinson and Blackburn

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell transcriptomics reveal pathways active in overnight culture TEC (ON TEC). (A, B) UMAP plot of E12.5, E13.5 and ON TEC with cells colored by time point (A) or by cluster, with percentages of cells belonging to each cluster (B). (C) Expression levels of the mTEC marker Tnfrsf11a and the early mTEPC marker Sox9 are similar in ON TEC and E13.5 TEC. (D) Notch signaling genes have similar expression in ON TEC. (E) The canonical NF-κB targets, Relb, Nfkb2 and Psmb9, are higher in ON TEC (top row). High UEA1 fluorescence (lectin_UEA1) suggesting a mixed phenotype (middle row). Wnt target genes, Pfn1, Cdc42 and Calm1, are expressed more highly in ON TEC (bottom row and Supplementary Tables 4, 5 ).