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. 2023 Jul 25;14:1186712. doi: 10.3389/fphar.2023.1186712

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Copyright © 2023 Liang, Liu, Zhao, Luo, He, Li, Tang, Tang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Natural products target ECM. Natural products normalize ECM via reducing deposition, altering modification and inhibiting degradation of ECM. Existing research suggests that TGF-β, MMPs, VEGFA, integrins, DDR and so on, would be a drug target. These signaling pathways are intertwined. Simultaneously, flavonoids, phenols, polysaccharides, and saponins, etc. Could regulating ECM by triggering variations about cell biological behavior and phenotype. In addition, natural products also affect the macrophage polarization.