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. 2023 Jul 25;14:1186712. doi: 10.3389/fphar.2023.1186712

FIGURE 4.

FIGURE 4

The whole process management of cancer. Efforts to establish a whole-process management of cancer treatment is critical for global cancer control. Thus, we put forward the concept of three phases of the whole-process management of cancer with ECM remodeling. Phase I: Natura products reduce ECM deposition. Phase II: Natura products alter ECM modification. Phase III: Natura products regulate degradation of ECM. Therefore, the sequential treatment of cancer should be constructed to normalize the ECM, protect the normal tissue, reverse immunosuppressive factors and cells.