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. 2023 Jul 25;14:1186712. doi: 10.3389/fphar.2023.1186712
TME tumor microenvironment
ECM extracellular matrix
CAFs cancer-associated fibroblasts
TAMs tumor-associated macrophages
HA hyaluronic acid
MMPs matrix Metalloproteinases
HSPGs heparan sulfate proteoglycans
TGF-β transforming growth factor beta
CXCL12/10 C-X-C motif chemokine ligand 12/10
CXCR4/3 C-X-C motif chemokine receptor 4/3
CCR9 C-C motif chemokine receptors 9
CCL21/25 C-C motif chemokine ligand 21/25
MCP-1 monocyte chemoattractant protein-1
CSF-1 colony stimulating factor-1
IL-6 interleukin-6
PGE2 prostaglandin E2
α-SMA α-smooth muscle actin
FGF-2 fibroblast growth factor-2
PDGF platelet-derived growth factor
EGF epidermal growth factor
LOX lysyl oxidase
LOXL LOX-like protein
IGF insulin-like growth factor
HAPLN1 hyaluronan and proteoglycan-linked protein 1;
HMM-HA High molecular weight HA
LMM-HA low-molecular-mass HA
PLODs procollagen-lysine 1, 2-oxoglutarate 5-dioxygenases
TG2 tissue transglutaminase 2
ADAMs disintegrin and metalloproteinases
IGFBP-3 insulin-like growth factor-binding protein 3
VEGF-A vascular endothelial growth factor-A
TIMP tissue inhibitor of metalloproteinases
GF growth factors
MT1-MMP membrane type-1 matrix metalloproteinase
AP-1 activator protein-1
JAK2 Janus kinase 2
PCA prostate cancer
FAK focal adhesion kinase
u-PA urokinase-type plasminogen activator
GBM glioblastoma multiforme
SP-1 Specificity protein-1
Col X collagen X
Nrf2 nuclear factor-erythroid 2related factor 2
ECG Epicatechin-3-gallate
EGCG Epigalloccatechin-3-gallate
GCAFs gastric cancer-associated fibroblasts
PAI-1 plasminogen activator inhibitor-1
EMMPRIN extracellular matrix metalloproteinase inducer
TLR4 toll-like receptor 4
CDK6 cyclin-dependent kinase 6
SFDA State Food and Drug Administration of China
PD-L1 programmed death ligand-1
PD-1 programmed death-1
TGF-βR TGF-β receptor
EDB extra domain B
DDR1 discoid domain receptor 1