TABLE 2.
Effect of vitamin D supplementation compared with no vitamin D on primary and secondary outcomes
| Vitamin D | No vitamin D | HR or risk ratio1 (95% CI) | P value | |
|---|---|---|---|---|
| Primary outcome | ||||
| Fever, cough, or shortness of breath at baseline, n (%) | ||||
| No | 20 (22.2) | 27 (29.7) | ||
| Yes | 70 (77.8) | 63 (69.2) | ||
| Missing | 0 (0.0) | 1 (1.1) | ||
| Days to resolution, median (95% CI) (N = 132) | 3 (2-5) | 3 (2-4) | 0.92 (0.66, 1.30) | 0.650 |
| Secondary outcomes | ||||
| Fever at baseline, n (%) | ||||
| No | 45 (50.0) | 54 (59.3) | ||
| Yes | 45 (50.0) | 37 (40.7) | ||
| Days to resolution, median (95% CI) (N = 81) | 2 (2–2) | 2 (2–2) | 1.02 (0.65, 1.59) | 0.938 |
| Cough at baseline, n (%) | ||||
| No | 36 (40.0) | 35 (38.5) | ||
| Yes | 54 (60.0) | 56 (61.5) | ||
| Days to resolution, median (95% CI) (N = 109) | 3 (2–6) | 3 (2–4) | 0.88 (0.60, 1.28) | 0.498 |
| Shortness of breath at baseline, n (%) | ||||
| No | 77 (85.6) | 80 (87.9) | ||
| Yes | 13 (14.4) | 10 (11.0) | ||
| Missing | 0 (0.0) | 1 (1.1) | ||
| Days to resolution, median (95% CI) (N = 23) | 3 (2–5) | 2 (1–2) | 0.78 (0.33, 1.84) | 0.570 |
| Days to discharge, median (95% CI) (N = 147) | 6 (5–7) | 5 (4–6) | 0.82 (0.59, 1.14) | 0.236 |
| Need for assisted ventilation1 (N = 148), n (%) | ||||
| No | 70 (95.9) | 71 (94.7) | ||
| Yes | 2 (2.7) | 2 (2.7) | ||
| Missing | 1 (1.4) | 2 (2.7) | 1.00 (0.73, 1.38) | 0.998 |
Estimates based on univariable Cox or Poisson regression models.
P for the test of proportional hazards assumption (global test) >0.05 for all outcomes for which Cox regression models were performed.
1
Risk ratio calculated for the need for assisted ventilation; HR calculated for all other outcomes.