. Author manuscript; available in PMC: 2023 Nov 1.

Published in final edited form as: J Control Release. 2022 Oct 12;351:883–895. doi: 10.1016/j.jconrel.2022.09.067

Table 2.

Summary of selected drugs. Values for logP, molecular weight (MW), and polar surface area were obtained from PubChem. PTX = paclitaxel, Rapa = rapamycin, R-848 = resiquimod, DXR = doxorubicin, DXM = dexamethasone, cGAMP = 3′ 3’-cyclic guanosine monophosphate–adenosine monophosphate.

Drug	LogP	MW (g/mol)	Polar Surface Area (Å²)	Application
PTX	2.5	853.9	221.3	Chemotherapeutic
Rapa	6.0	914.2	195.0	Immunosuppressant
R-848	1.3	314.4	86.2	Vaccine Adjuvant
DXR	1.3	543.5	206.1	Chemotherapeutic
DXM	1.9	392.5	94.8	Immunosuppressant
cGAMP	−5.9	674.4	325.0	Vaccine Adjuvant