Table 3.
Results of the meta-regression analysis.
| Coefficient | SE | Z value | P value | 95% CI | |
|---|---|---|---|---|---|
| Apoptotic cells | |||||
| ⁃Intervention period (Reference >90 days) | |||||
| ✓30–90 days | 1.302 | 1.820 | 0.716 | 0.474 | −2.264–4.869 |
| ⁃Animal species (Reference mice) | |||||
| ✓Rats | −4.282 | 1.858 | −2.305 | 0.021 | −7.924–−0.641 |
| ✓Others | 0.518 | 2.472 | 0.209 | 0.834 | −4.328–5.363 |
| ⁃Sample source (Reference brain) | |||||
| ✓Kidney | 5.084 | 2.886 | 1.761 | 0.078 | −0.573–10.741 |
| ✓Liver | 1.338 | 2.707 | 0.494 | 0.621 | −3.968–6.644 |
| ✓Others | 2.142 | 2.603 | 0.823 | 0.411 | −2.960–7.243 |
| Bax | |||||
| Intervention period (Reference <30 days) | |||||
| ✓30–90 days | −0.800 | 2.578 | −0.310 | 0.756 | −5.853–4.253 |
| ✓> 90 days | −4.971 | 2.778 | −1.789 | 0.074 | −10.416–0.475 |
| ⁃Animal species(Reference mice) | |||||
| ✓Rats | −4.598 | 2.179 | −2.110 | 0.035 | −8.868–−0.328 |
| ✓Others | −0.984 | 2.226 | −0.442 | 0.658 | −5.346–3.379 |
| ⁃Sample source (Reference brain) | |||||
| ✓Kidney | 3.785 | 2.993 | 1.264 | 0.206 | −2.082–9.651 |
| ✓Others | 1.588 | 2.499 | 0.635 | 0.525 | −3.311–6.486 |
| Bcl-2 | |||||
| ⁃Intervention period (Reference <30 days) | |||||
| ✓30–90 days | −0.865 | 1.941 | −0.446 | 0.656 | −4.668–2.939 |
| ✓> 90 days | −1.144 | 2.050 | −0.558 | 0.577 | −5.163–2.875 |
| ⁃Animal species(Reference mice) | |||||
| ✓Rats | 2.812 | 1.244 | 2.261 | 0.024 | 0.374–5.250 |
| ✓Others | 1.309 | 1.380 | 0.948 | 0.343 | −1.396–4.013 |
| ⁃Sample source (Reference brain) | |||||
| ✓Kidney | −1.666 | 1.988 | −0.838 | 0.402 | −5.563–2.231 |
| ✓Liver | 0.498 | 2.160 | 0.231 | 0.818 | −3.736–4.732 |
| ✓Others | 0.940 | 1.528 | 0.615 | 0.538 | −2.054–3.934 |
| Caspase-3 | |||||
| ⁃Intervention period (Reference <30 days) | |||||
| ✓30–90 days | 1.968 | 2.665 | 0.739 | 0.460 | −3.255–7.192 |
| ✓> 90 days | 4.344 | 3.436 | 1.264 | 0.206 | −2.391–11.078 |
| ⁃Animal species(Reference mice) | |||||
| ✓Rats | 3.444 | 2.213 | −1.556 | 0.120 | −7.782–0.895 |
| ✓Others | −4.054 | 2.230 | −1.818 | 0.069 | −8.424–0.316 |
| ⁃Sample source (Reference Kidney) | |||||
| ✓Liver | 0.799 | 2.692 | 0.297 | 0.767 | −4.477–6.075 |
| ✓Others | 1.541 | 2.334 | 0.660 | 0.509 | −3.034–6.116 |
| Cytochrome c | |||||
| ⁃Intervention period (Reference <30 days) | |||||
| ✓30–90 days | 2.272 | 1.481 | 1.534 | 0.125 | −0.630–5.174 |
| ✓> 90 days | 0.248 | 1.687 | 0.147 | 0.883 | −3.058–3.555 |
| ⁃Animal species(Reference mice) | |||||
| ✓Rats | −1.417 | 1.537 | −0.922 | 0.357 | −4.430–1.596 |
| ✓Others | −2.931 | 1.315 | −2.229 | 0.026 | −5.508–−0.354 |
| ⁃Sample source (Reference kidney) | |||||
| ✓Liver | 0.147 | 1.866 | 0.079 | 0.937 | −3.511–3.805 |
| ✓Others | 1.641 | 1.776 | 0.924 | 0.355 | −1.840–5.122 |