Table 3.

Potential drug candidate for the therapeutic target of the PERK signaling pathway (5,6,82,105)

Name of the drugs	Therapeutic target	Functions	p-eIF2α	Disease effects	Disease
CCT020312	PERK	Activation	↑	Beneficial	MS, cancer
MK-28	PERK	Activation	↑	Beneficial	HD
CCT020312	PERK	Activation	↑	Beneficial	HD
GSK2606414	PERK	Inhibition	↓	Beneficial	AD, PD, ALS
GSK2656157	PERK	Inhibition	↓	Beneficial	Cancer
Salubrinal	GADD34	Inhibition	↑	Beneficial	MS, ALS
Guanabenz	GADD34	Inhibition	↑	Beneficial	MS, ALS
Sephin1	GADD34	Inhibition	↑	Beneficial	MS, ALS

‘↑’ indicates ‘increase"‘↓’ indicates ‘decrease"‘→’ inicates ‘no changes’