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. 2023 Jul 24;19(8):e11493. doi: 10.15252/msb.202211493

Figure 5. The PT network state is subject to gene–environment interaction.

Figure 5

  1. Comparison of PT score based on our proteome data and PT score based on transcriptome data from (Smith & Kruglyak, 2008) for 99 strains grown on glucose and present in both datasets.
  2. Distribution of PT scores for 109 strains grown in glucose (left) or ethanol (right) based on transcriptome data from (Smith & Kruglyak, 2008).
  3. PCA of transcriptome variability for 109 strains grown in glucose or ethanol as indicated. Calculation of Eigenvalues, coloring by PT score, and labeling as in Fig 2A.
  4. QTL mapping of PT score for 99 strains grown in glucose (blue) and ethanol (orange). 15% FDR threshold indicated by dashed red line.
  5. Correlation of PT score based on proteomic data for several kinase KO strains with metabolite measurements (Zelezniak et al, 2018).

Source data are available online for this figure.