Figure 1. Spearman's correlation between DMS datasets and VEPs.

The Spearman's correlation between all VEPs and the selected DMS datasets for every protein. The top‐performing VEP by Spearman's correlation for each protein is labelled on the plot. DMS experiments are grouped by the type of fitness assay employed. “Yeast complementation” describes an assay where the human gene is used to compensate for the lack of activity in an essential yeast gene. “Growth or survival” includes any assay where growth rate (and lack of growth) is assessed excluding yeast complementation assays. “Expression level” includes VAMP‐seq and other assays that quantify the amount of protein produced. “Interaction” includes any assays that quantify a protein's interaction with binding partners such as yeast two‐hybrid. “Protein specific” includes any assay tailored to assessing the function of a particular protein that does not fall easily into another category.