Table 2. Secondary Analyses of Cognitive Function for Out-of-Hospital Cardiac Arrest Survivors With Hypothermia vs Normothermiaa.
Outcome assessmentb | All including dead; P value | Model 1: survivors at 6 mo only | Model 2: survivors at 6 mo with adjustments for clinical characteristics | ||
---|---|---|---|---|---|
Mean difference (95% CI) | P value | Mean difference (95% CI) | P value | ||
MoCA-30c | .88 | 0.36 (−0.33 to 1.05) | .37 | 0.38 (−0.29 to 1.05) | .27 |
SDMT z score | .82 | 0.06 (−0.16 to 0.27) | .62 | 0.03 (−0.19 to 0.25) | .77 |
Abbreviations: MoCA, Montreal Cognitive Assessment; SDMT, Symbol Digit Modalities Test.
Performed by mixed-effects linear regression: model 1, adjustment for site (random intercept) and coenrollment in the TAME trial, model 2 also including adjustment for age (younger than 65 years and 65 years or older; MoCA only), sex (male or female), and pre-arrest Clinical Frailty Score (1 to 4 and 5 to 9).
Number of outcome assessments (hypothermia or normothermia), MoCA-30, including dead (849 of 930 vs 822 of 931) and including survivors only (384 of 460 vs 376 of 479), and SDMT including dead (768 of 930 vs 744 of 931) and including survivors only (303 of 460 vs 298 of 479).
Including converted T-MoCA.