TABLE 1.

S1PR expression in intestinal cells under homeostasis or inflammation.

	Expression of S1PRs under homeostasis					Expression of S1PRs under inflammation
	IECs	Mφ	DCs	NK cell	N	IECs	Mφ	DCs	NK cell	N
S1PR1	+	+++	+++	+	+++	-	-	↑	-	↑
S1PR2	+++	+++	+++	+	++	-	↑	↑	-	↑
S1PR3	++	+	+++	-	++	-	-	↑	-	↑
S1PR4	-	+	++	++	+++	-	-	-	-	-
S1PR5	++	-	++	+	+	-	-	-	↑	-

Note: The profile of S1PR expression varies in different types of cells in the intestine.

“↑” represents the increased expression of specific S1PR in specific cells under inflammation.

“-” represents no level change or unknown condition.

Abbreviations: IECs, intestinal epithelial cells; Mφ, macrophages; DCs, dendritic cells; N, neutrophils; S1PR1∼5, sphingosine-1-phosphate receptor 1–5.