Table 1.

Optimization of Pd-Catalyzed Conjunctive Cross-Coupling employing Phosphinooxazoline Ligands.^a

ligand	R1	R	yield (%)b	erc
L5	i-Pr	Ph	71	95:5
L9	t-Bu	Ph	70	95:5
L10	Me	Ph	75	95:5
L11	Ph	Ph	83	97:3
L12	Ph	2-furyl	85	93:7
L13	Ph	mesityl	13	93:7
L14	Ph	o-tolyl	trace	NA
L15	Ph	Cy	55	94:6
L16	Ph	3,5-xylyl	84	97:3

^(a)1 (0.2 mmol), 2 (0.22 mmol), solvent (0.8 mL)

^(b)Yields are of ioslated material after column chromatography.

^(c)Enantiomer ratio determined by chiral SFC analysis.