Table 6.
Stability results for decitabine (DCB) and venetoclax (VTX) in rat plasma at different conditions.
| Analyte | Concentration (ng/mL) |
Short term stability at room temperature (24 h) |
Auto sampler stability at −10 °C (24 h) |
Freeze and thaw stability at −80 °C (3 cycles) |
Long term stability at −80 °C (30 days) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Recovery (%) | RSD (%) | Recovery (%) | RSD (%) | Recovery (%) | RSD (%) | Recovery (%) | RSD (%) | |||
| Decitabine | QCL | 15.0 | 97.28 | 5.69 | 95.04 | 2.77 | 98.55 | 4.25 | 96.02 | 5.28 |
| QCM | 1400.0 | 95.87 | 3.47 | 103.12 | 4.37 | 93.81 | 6.48 | 94.42 | 1.88 | |
| QCH | 2300.0 | 93.35 | 8.14 | 95.83 | 0.51 | 98.73 | 3.18 | 95.40 | 2.90 | |
| Venetoclax | QCL | 15.0 | 99.15 | 2.90 | 97.20 | 3.16 | 91.91 | 4.83 | 94.46 | 2.94 |
| QCM | 500.0 | 95.74 | 3.68 | 94.62 | 1.08 | 93.16 | 3.79 | 105.13 | 5.14 | |
| QCH | 800.0 | 102.02 | 7.34 | 93.79 | 5.25 | 103.94 | 1.57 | 95.37 | 1.53 | |
| n | 3 | 3 | 3 | 3 | ||||||