Table 1.

Optimization of the method of preparation of nanoformulations.

No	Code	D:P (mg)	Stabilizer 1% (10 mL)	Preparation method	P.Size (nm)	Z.P (mv)	PDI	E.E (%)
01	PTX 05	1:10	Pluronic F-127	Solvent evaporation	190 ± 13.2	−8.1 ± 1.8	0.2 ± 0.03	71
02	PTX 06	2:10			226 ± 11.6	−9 ± 0.7	0.16 ± 0.01	96
03	PTX 07	1:10		Nano-precipitation	409 ± 10.4	−6.1 ± 1.2	0.59 ± 0.1	73
04	PTX 08	2:10			542 ± 13.8	−5.8 ± 0.1	01	52
05	PTX 21	1:10	Poloxamer 407	Solvent evaporation	249 ± 9.7	−5.6 ± 0.21	0.19 ± 0.01	83
06	PTX 22	2:10			255 ± 14.2	−6.9 ± 0.11	0.3 ± 0.02	67
07	PTX 23	1:10		Nano-precipitation	399 ± 12.4	−3.09 ± 1.4	0.46 ± 0.04	69
08	PTX 24	2:10			475 ± 10.5	−5.22 ± 0.8	0.91 ± 0.03	75

Organic solvent: ACN (5 mL), D: Paclitaxel, P: PLGA.