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. 2023 Jul 6;31(9):101697. doi: 10.1016/j.jsps.2023.101697

Table 9.

Results of paclitaxel nanoformulations with different concentrations of mannitol after freeze drying.

Code Formulations
Blank
2 % Mannitol
5 % Mannitol
10 % Mannitol
PS(nm) PDI ZP(mv) PS(nm) PDI ZP(mv) PS(nm) PDI ZP(mv) PS(nm) PDI ZP(mv) PS(nm) PDI ZP(mv)
PTX 84 190 ± 12.42 0.13 ± 0.02 −30 ± 1.1 237 ± 1.15 0.19 ± 0.01 −24.3 ± 2.2 244 ± 13.2 0.2 ± 0.08 −31.1 ± 1.5 185 ± 2.8 0.1 ± 0.2 −31.2 ± 1.2 298 ± 9.1 0.35 ± 1.8 −24.4 ± 1.1
PTX 86 287 ± 13.51 0.2 ± 0.01 −35.8 ± 1.2 329 ± 15.5 0.3 ± 0.1 −34.3 ± 1.5 350 ± 1.9 0.19 ± 0.03 −30 ± 2.5 293 ± 17.2 0.18 ± 1.2 −36.4 ± 2.9 377 ± 6.9 0.4 ± 1.2 −29.7 ± 1.1
PTX 108 202 ± 14.5 0.17 ± 0.03 −35.2 ± 0.1 293 ± 12.3 0.2 ± 0.15 −29.0 ± 2.3 280 ± 2.4 0.23 ± 0.02 –33.4 ± 1.4 190 ± 14.1 0.2 ± 0.11 −35.1 ± 1.3 356 ± 17.3 0.2 ± 1.2 −34.3 ± 1.2
PTX 112 229 ± 13.24 0.2 ± 0.01 −40.4 ± 1.6 312 ± 6.09 0.4 ± 0.11 −38.4 ± 1.7 305 ± 3.31 0.24 ± 0.02 −36.9 ± 1 211 ± 3.1 0.2 ± 0.9 −38.9 ± 2.9 308 ± 24.3 0.5 ± 1.3 −29.1 ± 2.4