Table 2. Areas under the Curve of Variable Parameters for Determining the CAP-Induced ARDS and Evaluating Effect after CAP with and without ARDS Treatment^a.

name	AUC	sensitivity	specificity	P	95% CI
					lower limit	higher limit
nARDS-pre vs ARDS-pre
N2,N2-dimethylguanosine	0.771	0.607	0.961	0.0030	0.623	0.893
1-methylinosine	0.762	0.785	0.769	0.0166	0.615	0.887
3-methylguanine	0.755	0.678	0.692	0.0005	0.591	0.881
1-methyladenosine	0.724	0.678	0.807	0.0079	0.578	0.865
pantothenic acid	0.706	0.785	0.538	0.0187	0.562	0.839
uric acid	0.688	0.571	0.693	0.0101	0.531	0.825
7-methylguanine	0.638	0.571	0.692	0.0812	0.555	0.831
5 purines combination	0.900	0.821	0.885	9.3 × 10–6	0.810	0.988
PSI score	0.723	0.714	0.730	0.0191	0.582	0.861
APACHE II score	0.853	0.751	0.846	3.1 × 10–5	0.761	0.942
nARDS-pre vs nARDS-post
phytosphingosine	0.701	0.538	0.846	0.0150	0.562	0.838
L-phenylalanine	0.692	0.807	0.615	0.0110	0.550	0.833
N-acetylaspartylglutamate	0.681	0.692	0.538	0.0100	0.531	0.818
3 metabolites combination	0.811	0.730	0.769	0.0002	0.688	0.912
CRP	0.909	0.961	0.807	6.18 × 10–9	0.811	0.987
PCT	0.796	0.692	0.769	0.0028	0.677	0.905
ARDS-pre vs ARDS-post
L-phenylalanine	0.725	0.607	0.786	0.0040	0.580	0.850
N-acetylaspartylglutamate	0.721	0.857	0.571	0.0030	0.578	0.839
phytosphingosine	0.677	0.571	0.714	0.0320	0.538	0.811
3 metabolites combination	0.821	0.714	0.821	6.2 × 10–5	0.702	0.822
CRP	0.897	0.857	0.982	6.37 × 10–9	0.797	0.98
PCT	0.905	0.964	0.785	0.0033	0.804	0.971

^aAbbreviation: PSI: pneumonia severity index; APACHE II: acute physiology and chronic health evaluation II score; CAP: community-acquired pneumonia; ARDS: acute respiratory distress syndrome; nARDS: CAP without ARDS; nARDS-pre: nARDS patients before treatment; nARDS-post: nARDS patients after treatment; ARDS-pre: ARDS patients before treatment; ARDS-post: ARDS patients after treatment; AUC: area under the curve. CRP, c-reactive protein; PCT, procalcitonin.