Table 1. Gene Products of FDA-Approved Cancer Biomarkers That Undergo Ectodomain Sheddinga.
| gene product | cancer |
|---|---|
| EGFR | colorectal cancer; |
| non-small cell lung cancer | |
| FGFR2 | cholangiocarcinoma |
| FGFR3 | urothelial cancer |
| ERBB2 (HER2) | breast cancer; |
| gastric and gastroesophageal cancer | |
| c-KIT | gastrointestinal stromal tumors |
| KIT | aggressive systemic mastocytosis |
| MET | non-small cell lung cancer |
| NTRK1 | solid tumors with NTRK gene fusion |
| NTRK2 | solid tumors with NTRK gene fusion |
| NTRK3 | solid tumors with NTRK gene fusion |
| PDGFRB | myelodysplastic syndrome/myeloproliferative disease |
| PD-L1 | breast cancer cervical cancer; |
| esophageal squamous cell carcinoma; | |
| gastric or gastroesophageal junction adenocarcinoma; | |
| head and neck squamous cell carcinoma; | |
| non-small cell lung cancer; | |
| triple-negative Breast Carcinoma; | |
| urothelial carcinoma |
a
This table is a partial list from ref (7).