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. Author manuscript; available in PMC: 2024 Jul 13.
Published in final edited form as: J Med Chem. 2023 Jun 29;66(13):9076–9094. doi: 10.1021/acs.jmedchem.3c00664

Scheme 1.

Scheme 1.

Synthesis of an Analogue of 1 Containing Azetidinea

aReagents and conditions: (a) Na2CO3, Pd(PPh3)4, 1,2-dimethoxyethane (DME)-H2O (4:1), 80 °C, overnight, 57%; (b) LiOH, tetrahydrofuran (THF)-MeOH-H2O (3:1:1), rt, 3 h, 47%.