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Preparation of Double (A) and Mono (A and B) Prodrugs of 15 (i.e., 49–51) as well as Double Prodrug 62 of 1 (C)a
aReagents and conditions: (a) 2-chloro-N,N-dimethylacetamide, Cs2CO3, DMF, rt, overnight, 56%-quantitative; (b) TFA, DCM, rt, 1 h, 59%; (c) ethyl chloroformate, N,N-diisopropylethylamine, DMF, rt, overnight, 17–62%.
