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. Author manuscript; available in PMC: 2024 Jul 13.
Published in final edited form as: J Med Chem. 2023 Jun 29;66(13):9076–9094. doi: 10.1021/acs.jmedchem.3c00664

Chart 1.

Chart 1.

Stuctures and Reported Potencya of Representative P2Y14R Antagonists, Derived from Lead Piperidine 1 (Including C-Bridged 2 and Uncharged 3 Bioisosteres) and Recently Reported 2-Phenyl-benzoxazole Acetamide 4a and 5-Amido-1H-pyrazole-3-carboxylic Acid 4b Derivatives 20,21

bInhibitory activity in a cAMP assay.16,20aIC50 in a fluorescent binding assay, unless noted.