Table 3.
Previously Published Structures with Piperidine Ring Variation Showing the Effect on P2Y14R Binding Affinity Associated with an α-Hydroxyl Substituent
R = | ICso (P2Y14R), nMa | Reference |
---|---|---|
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2.2b | Belley et al.15 |
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6.3 b | Belley et al.15 |
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38.3±2.0 | Wen et al.5 |
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117±38 | Wen et al.5 |
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696±100 | Wen et al.5 |
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21.3±1.2 | Wen et al.5 |
Human P2Y14R, unless noted.
Nonhuman primate (chimpanzee) P2Y14R.