. Author manuscript; available in PMC: 2024 Jul 13.

Published in final edited form as: J Med Chem. 2023 Jun 29;66(13):9076–9094. doi: 10.1021/acs.jmedchem.3c00664

Table 3.

Previously Published Structures with Piperidine Ring Variation Showing the Effect on P2Y₁₄R Binding Affinity Associated with an α-Hydroxyl Substituent


R =	ICso (P2Y₁₄R), nM^a	Reference
	2.2^b	Belley et al.¹⁵
	6.3 ^b	Belley et al.¹⁵
	38.3±2.0	Wen et al.⁵
	117±38	Wen et al.⁵
	696±100	Wen et al.⁵
	21.3±1.2	Wen et al.⁵

Human P2Y₁₄R, unless noted.

Nonhuman primate (chimpanzee) P2Y₁₄R.