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Synthesis of 4-and 5-substituted alkynyl analogs. For the 4-position, aldehyde (11) was converted to alkene (49) or alkyne (51) through Wittig reaction or through Seyferth-Gilbert homologation respectively. For the 5-substituted analogs, lack of available building blocks with appropriate functionality at the 5 position makes the synthesis a more challenging task. Blocking of the 2-position through a Suzuki reaction proved to be the optimum choice.
