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. Author manuscript; available in PMC: 2023 Aug 8.
Published in final edited form as: J Med Chem. 2022 Aug 19;65(17):11788–11817. doi: 10.1021/acs.jmedchem.2c00909

Figure 5:

Figure 5:

(A) Time line of the experiment to determine IT50. (B) wash time vs cell survival (%) of NCI-H522 cells treated with RSL3 (0.5 μM) and 45 (2 μM) (approximately 2–3 times the corresponding IC50s). (C) Calculated IT50s. To mitigate the effects of the process on cell proliferation, each data point is represented as % of the corresponding data point of DMSO treated cells. Data are mean ± SD (n=3).