Table 4.

IC₅₀ ± SD (n = 3) values (μM) for ML210, BCP-T.A, BCP-C.A and BCP-P.A on NCI-H522 (in the presence or absence of Liproxstatin-1 (0.25 μM)), HT-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38 and MEFS cell lines Data are mean ± SD (n=3).

Cell Line╲Compound	ML-210	BCP-T.A	BCP-C.A	BCP-P.A
NCI-H522	0.044 ± 0.005	0.017 ± 0.002	0.752 ± 0.083	1.129 ± 0.180
NCI-H522 + Lirpoxstatin-1	34.515 ± 6.182	7.894 ± 0.811	3.098 ± 0.243	2.879 ± 0.251
Fold Change*	784.431	464.353	4.120	2.550
HT-1080	0.022 ± 0.003	0.019 ± 0.003	0.302 ± 0.017	0.376 ± 0.008
MDA-MB-468	0.066 ± 0.006	0.084 ± 0.005	1.746 ± 0.153	0.065 ± 0.076
MDA-MB-231	0.020 ± 0.004	0.021 ± 0.003	0.494 ± 0.054	0.038 ± 0.004
HeLa	0.253 ± 0.041	0.242 ± 0.019	2.111 ± 0.110	0.303 ± 0.020
HCT-116	> 1.000	> 1.000	1.641 ± 0.528	3.801 ± 0.447
U2OS	0.822 ± 0.249	0.367 ± 0.055	1.708 ± 0.278	0.638 ± 0.016
WI-38	0.060 ± 0.004	0.022 ± 0.004	1.742 ± 0.222	0.500 ± 0.036
MEFS	0.016 ± 0.003	0.010 ± 0.001	0.352 ± 0.032	0.082 ± 0.008

^*Fold change is the ratio of IC₅₀ (NCI-H522 + Lirpoxstatin-1)/ IC₅₀ (NCI-H522).