TABLE 3.
Systemic replication of human H5N1 viruses in chickensa
| Virus | Virus titer (mean log PFU ± SD/g) in:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Lungs | Nasal turbinates | Spleen | Liver | Kidneys | Brain | Pancreas | Colon | |
| HK483 | 6.5 ± 0.6 | 6.8 ± 0.4 | 5.2 ± 0.3 | 5.1 ± 0.3 | 4.9 ± 0.5 | 3.6 ± 0.7 | 4.8 ± 0.2 | 5.1 ± 0.5 |
| HK486 | 5.3 ± 0.9 | 4.1 ± 1.3 | 5.1 ± 0.7 | 5.3 ± 0.7 | 4.2 ± 0.9 | 3.7 ± 0.9 | 3.8 ± 0.9 | 4.8 ± 0.3 |
a
Specific-pathogen-free chickens (2 weeks old) were infected intranasally and orally with 100 μl of virus (total, 105 PFU). Three chickens from each virus-infected group were sacrificed 1 day after infection for virus titration. By day 3, all of the chickens infected with either HK483 or HK486 had died.