Fig. 11.

IOA-289 regulates cell apoptosis of HLE, KKU-M213, PANC-1 and HT-29 gastrointestinal cancer cell lines upregulating apoptosis-related proteins. A human apoptosis antibody array was used to identify up to 43 differentially expressed apoptosis-related proteins in untreated control cells compared to cells incubated with 12 uM IOA-289 for 24 h. Representative images were randomly selected from at least 3 independent experiments. In graph have been reported the differently expressed proteins in the cells treated with IOA-289, with the cut-off value set at a fold-change ≥ 1,5. Upregulated proteins in common between cell lines are highlighted with different colors