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. 2023 Aug 8;42:197. doi: 10.1186/s13046-023-02780-4

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Analysis of changes in cell cycle phases during treatment with IOA-289. Cells from CRC, HCC, PC and CCA were cultured to a > 80% confluence and then treated with 3, 9 and 12 µM IOA-289 for 24 h. The different cell cycle phases were visualized by staining with Biocolor Cell-Clock™ Cell Cycle Assay. Following dye uptake and incubation a distinct color change occurs within cells, with particular color changes being associated with cells in the G0-G1(yellow), S (green), G2 and M Phases (blu). IOA-289 determines an arrest of the cell cycle in S phase, as can be observed particularly for KKU-M213, HLE and PANC-1 cells (*P < 0.05)