Table 2.

Results of meta-analysis comparing AR and PSR for CRLM

		Patients				Study heterogeneity
Outcomes of interest	Studies	AR	PSR	WMD/RR/HR (95% CI)	P value	I2(%)	P value	Effect model
Long-term
Overall survial (OS)	22	3154	4074	1.08(0.95–1.22)	0.245	49.3	0.005	Random
3‐year OS	13	1668	2878	0.99(0.92–1.06)	0.728	55.4	0.008	Random
5‐year OS	18	2760	3692	0.93(0.86–1.00)	0.054	44.9	0.021	Random
Disease‐free survival (DFS)	14	2260	3368	1.09(0.94–1.28)	0.259	75.1	< 0.001	Random
3‐year DFS	10	1237	2581	0.98(0.89–1.07)	0.66	0	0.897	Fixed
5‐year DFS	14	2260	3368	0.88(0.73–1.07)	0.212	70.1	< 0.001	Random
3‐year Liver-RFS	5	386	496	1.02(0.9–1.15)	0.789	0	0.79	Fixed
5‐year Liver-RFS	5	386	496	1.00(0.88–1.14)	0.981	0	0.592	Fixed
Short‐term
Duration of operation (min)	13	1234	1364	51.48(29.03–73.93)	< 0.001	98.6	< 0.001	Random
Estimated blood loss (mL)	10	886	992	189.92(21.39–358.45)	0.027	98.6	< 0.001	Random
Intraoperative blood transfusion	12	1799	3004	2.24(1.54–3.26)	< 0.001	74	< 0.001	Random
Length of hospital stay (day)	15	1813	3011	1.00(0.34–1.67)	0.003	66.6	< 0.001	Random
Positive margin (mm)	12	1244	1080	0.77(0.61–0.97)	0.024	33.9	0.119	Fixed
Postoperative complications	12	1880	3116	2.28(1.88–2.77)	< 0.001	0	0.639	Fixed
90‐day mortality	7	1711	2826	3.08(1.88–5.03)	< 0.001	0	0.796	Fixed
Intrahepatic recurrence	15	2299	2036	0.90(0.82–0.98)	0.021	26.2	0.166	Fixed
Repeat hepatectomy	14	2362	3398	0.64(0.55–0.76)	< 0.001	12.4	0.317	Fixed

Abbreviations: AR Anatomic resection, CI Confidence interval, CRLM Colorectal liver metastases, DFS Disease-free survival, HR Hazard ratio, RR Risk ratio, OS Overall survival, PSR Parenchymal-sparing resection, RFS Recurrence‐free survival, WMD Weighted mean difference