Table 2.

MiRNAs differentially expressed between the cladribine treated and untreated conditions that target selected genes.

miRNA	NIBAN2	NLHRC2	PPIF	JUN	Cladribine
miR-484	yes	yes			↓
let-7g-5p	yes	yes	yes		↓
miR-29c-3p	yes	yes		yes	↓
miR-15a-5p		yes		yes	↓
miR-8063		yes			↑
miR-29b-3p		yes		yes	↓
miR-192-5p		yes			↓
miR-26b-5p		yes		yes	↓
miR-29a-3p		yes		yes	↓
miR-30b-5p		yes		yes	↓
miR-30e-5p		yes		yes	↓
miR-21-5p			yes		↓
miR-27a-3p			yes		↓
miR-27b-3p			yes		↓
miR-128-3p			yes		↓
miR-106b-5p			yes		↓
miR-152-3p			yes		↓
miR-500a-3p			yes		↓
miR-766-3p				yes	↑
miR-532-5p				yes	↓
miR-99a-5p				yes	↓
miR-21-3p				yes	↓

↑ denotes upregulation of miRNA expression and ↓ denotes downregulation of miRNA expression by cladribine. “Yes” indicate that the gene is a target of the corresponding miRNA. In bold, miRNAs selected for ex vivo validation.