Table 2.

Adverse events grade 1 or 2 occurring in ≥10% of patients and recorded grade 3, 4, and 5 events by patient.

94 patients Treated by Proton Therapy		Grade*
		2	3	4
EVENTCATEGORY	EVENTDESCRIPTION	N(%)	N(%)	N(%)
Blood and lymphatic system disorders	Anemia		1(1%)
	Blood and lymphatic system disorders		1(1%)
Endocrine disorders	Adrenal insufficiency		1(1%)
	Endocrine disorders		1(1%)
Eye disorders	Eye disorders			1(1%)
Gastrointestinal disorders	Gastritis		1(1%)
	Gastrointestinal disorders		3(3%)
	Vomiting		2(2%)
Infections and infestations	Catheter related infection		1(1%)
	Device related infection		1(1%)
	Sepsis			1(1%)
Metabolism and nutrition disorders	Dehydration		1(1%)
	Hypernatremia			2(2%)
	Hyponatremia			1(1%)
Nervous system disorders	Central nervous system necrosis		2(2%)
	Dysarthria		1(1%)
	Dysphasia		1(1%)
	Headache	17(18%)
	Headache		6(6%)
	Hydrocephalus		1(1%)
	Hypersomnia		1(1%)
	Nervous system disorders		3(3%)
	Oculomotor nerve disorder		1(1%)
	Paresthesia		1(1%)
	Seizure		5(5%)
	Stroke		1(1%)
Psychiatric disorders	Psychiatric disorders		1(1%)
	Psychosis		1(1%)
Respiratory, thoracic and mediastinal disorders	Respiratory, thoracic and mediastinal disorders	13(14%)
	Respiratory, thoracic and mediastinal disorders		1(1%)
Surgical and medical procedures	Surgical and medical procedures		2(2%)
Vascular disorders	Thromboembolic event		2(2%)
	Vascular disorders		6(6%)

^*CTCAE v 4.0, no patient experienced a grade 5 event.