TABLE 1.
Pooled Baseline Characteristics of Patients in the ASCEND and CAPACITY Clinical Studies and the Inova Registry
| Pooled ASCEND and CAPACITY Studiesa | Inova Registry | ||
|---|---|---|---|
| Pirfenidone (N = 623) | Placebo (N = 624) | BSC (N = 286) | |
| Age, years | 68.0 (45-80) | 68.0 (40-80) | 67.0 (43-80) |
| Male, % | 74.3 | 74.5 | 81.8 |
| Caucasian, % | 95.0 | 94.6 | NA |
| FVC % predicted | 71.1 (48-124) | 70.3 (48-136) | 68.0 (50-114) |
| DLco % predicted | 44.0 (27-81) | 44.1 (27-170) | 46.0 (30-102) |
| 6MWD (m) | 400.0 (112-731) | 413.5 (163-716) | NA |
| UCSD SOBQ score | 31.0 (0-100) | 31.5 (0-105) | NA |
| FEV1/FVC ratio | 0.84 (0.69-0.99) | 0.84 (0.69-0.97) | 0.84 (0.70-1.15) |
Note: Data presented are median (range) or % unless otherwise stated.
aPooled CAPACITY and ASCEND data: Reproduced with permission of the European Respiratory Society. Eur Respir J. 2016;47(1):243-53.25
6MWD = 6-minute walk distance; BSC = best supportive care; DLco = carbon monoxide diffusing capacity; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; NA = not available; UCSD SOBQ = University of California, San Diego, Shortness of Breath Questionnaire.