Table 3.
Differentially expressed citrullinated proteins with corresponding citrullinated peptides and related biological processes and functions
| UniProt ID | Name | Peptide | Citrullinated peptides | Total protein | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| AngII_14d_vector_14d vs. Sham | AngII_14d_vector_14d vs. AngII_14d_PADinh_14d | AngII_14d_vehicle_14d/Sham | AngII_14d_vehicle_14d/AngII_14d_PADinh_14d | |||||||
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| Log2FC | FDR (p value) | Log2FC | FDR (p value) | Log2FC | FDR (p value) | Log2FC | FDR (p value) | |||
| P09103 | PDIA1 | RcitTGPAATTLSDTAAAESLVDSSEVTVIGFFK | 2.634 | 0.0154 | 0.915 | 0.1470 | 0.340 | 0.0205 | 0.321 | 0.7141 |
| Q91YQ5 | RPN1 | RcitTVDLSSHLAK | 1.532 | 0.0267 | 1.095 | 0.0893 | 0.392 | 0.0821 | 0.354 | 0.5222 |
| O88851 | RBBP9 | EQQEVADRcitLDAK | 1.219 | 0.0213 | -0.406 | 0.1872 | 0.252 | 0.4780 | -0.481 | 0.0046 |
| P01942 | HBA | IGGHGAEYGAEALERcitMFASFPTTK | 1.070 | 0.2919 | 0.837 | 0.3916 | 0.660 | 0.0000 | 0.428 | 0.0000 |
| Q9D2G2 | ODO2 | AAVEDPRcitVLLLDL | 1.030 | 0.2433 | -0.674 | 0.2014 | -0.083 | 0.7993 | -0.304 | 0.0000 |
| Q02566 | MYH6 | TTHPHFVRcitCIIPNERK | 0.983 | 0.4194 | -0.362 | 0.7249 | -0.182 | 0.8306 | -0.421 | 0.0000 |
| Q8QZT1 | THIL | MNISRQEQDTYALSSYTRcitSK | 0.961 | 0.2266 | -0.398 | 0.4059 | -0.112 | 0.8219 | -0.248 | 0.0000 |
| P11499 | HS90B | EQVANSAFVERcitVRK | 0.961 | 0.3747 | -0.713 | 0.2981 | 0.040 | 0.8212 | -0.039 | 0.8222 |
| P00920 | CAH2 | DFPIANGDRcitQSPVDIDTATAQHDPALQPLLISYDK | 0.926 | 0.1806 | 0.499 | 0.4385 | 0.747 | 0.0000 | 0.502 | 0.0000 |
| P09103 | PDIA1 | KEECPAVRcitLITLEEEMTK | 0.802 | 0.3716 | 3.521 | 0.0470 | 0.340 | 0.0205 | 0.321 | 0.7141 |
| P07724 | ALBU | DDNPSLPPFERcitPEAEAM (UniMod_35) CTSFK | 0.793 | 0.0420 | 0.523 | 0.1482 | 0.440 | 0.0000 | 0.283 | 0.8284 |
| P68134 | ACTS | DLYANdeamNVMSGGTTMYPGIADRcitMQK | 0.790 | 0.1571 | -0.597 | 0.0835 | 0.251 | 0.7750 | -0.403 | 0.0000 |
| Q9JI91 | ACTN2 | VIQSYSIRISSSNPYSTVTMDELRcitNK | 0.788 | 0.4380 | -0.612 | 0.3349 | -0.123 | 0.8278 | -0.416 | 0.0000 |
| Q8VDD5 | MYH9 | DVDRcitIIGLDQdeamVAGMSETALPGAFK | 0.764 | 0.1436 | 0.777 | 0.1356 | 0.455 | 0.0000 | 0.393 | 0.0000 |
| Q9CZU6 | CISY | LRcitDYIWNTLNSGRVVPGYGHAVLRK | 0.725 | 0.5453 | -0.457 | 0.5816 | -0.186 | 0.7231 | -0.278 | 0.0000 |
| P08249 | MDHM | NSPLVSRLTLYDIAHTPGVAADLSHIETRcitANVK | 0.703 | 0.4811 | -0.346 | 0.6309 | -0.129 | 0.8274 | -0.263 | 0.0000 |
| P09541 | MYL4 | ESNGTVMGAELRcitHVLATLGEK | 0.683 | 0.2006 | 0.804 | 0.1467 | 0.710 | 0.0000 | 0.147 | 0.0000 |
| Q8BTM8 | FLNA | YAVRFIPRcitENGIYLIDVK | 0.652 | 0.1444 | 0.444 | 0.3994 | 0.629 | 0.0000 | 0.290 | 0.8273 |
| P01837 | IGKC | IDGSERcitQNGVLNSWTDQDSK | 0.649 | 0.1237 | 0.470 | 0.2127 | 0.709 | 0.0000 | 0.531 | 0.0000 |
| P27773 | PDIA3 | IFRDGEEAGAYDGPRcitTADGIVSHLK | 0.639 | 0.1752 | 0.514 | 0.2479 | 0.372 | 0.0000 | 0.321 | 0.0000 |
| P49312 | ROA1 | IEVIEIMTDRcitGSGK | 0.613 | 0.4353 | 0.091 | 0.8905 | 0.047 | 0.7877 | -0.016 | 0.7723 |
| P05977 | MYL1 | EGNdeamGTVM (UniMod_35) GAELRcitHVLATLGEK | 0.608 | 0.5163 | 0.926 | 0.3788 | 1.113 | 0.0000 | 0.953 | 0.0000 |
| Q99KI0 | ACON | NTIVTSYNRNFTGRcitNDANPETHAFVTSPEIVTALAIAGTLK | 0.608 | 0.4560 | -0.351 | 0.3920 | -0.160 | 0.8295 | -0.311 | 0.0000 |
| Q60605 | MYL6 | DQGTYEDYVEGLRcitVFDK | -0.609 | 0.2437 | -0.105 | 0.8919 | 0.569 | 0.0000 | 0.340 | 0.7251 |
| Q8BWT1 | THIM | QTM (UniMod_35) QVDEHARcitPQTTLEQLQK | -0.627 | 0.0681 | -0.512 | 0.2715 | -0.277 | 0.0000 | -0.301 | 0.0000 |
| P54071 | IDHP | GRPTSTNPIASIFAWTRGLEHRcitGK | -0.650 | 0.0473 | -0.080 | 0.9101 | -0.247 | 0.0000 | -0.468 | 0.0000 |
| P24549 | AL1A1 | LADLMERcitDRLLLATMEALNGGK | -0.654 | 0.3812 | -0.977 | 0.1483 | 0.687 | 0.0146 | 0.958 | 0.0000 |
| Q99JY0 | ECHB | AMDSDWFAQNYMGRcitK | -0.676 | 0.3669 | -0.878 | 0.1457 | -0.329 | 0.0000 | -0.366 | 0.0000 |
| Q9D6R2 | IDH3A | RIAEFAFEYARNNHRcitSNVTAVHK | -0.717 | 0.4830 | 0.693 | 0.6346 | -0.114 | 0.8165 | -0.224 | 0.0000 |
| Q9D6R2 | IDH3A | RIAEFAFEYARcitNNHRSNVTAVHK | -0.726 | 0.4782 | 0.655 | 0.6550 | -0.114 | 0.8165 | -0.224 | 0.0000 |
| Q9Z2I8 | SUCB2 | SENEPIENEAARcitYDLK | -0.817 | 0.1183 | -0.984 | 0.0919 | -0.201 | 0.8051 | -0.318 | 0.0000 |
| P07310 | KCRM | AGHPFM (UniMod_35) WNEHLGYVLTCPSNLGTGLRcitGGVHVK | -0.864 | 0.1456 | -1.202 | 0.0116 | -0.167 | 0.8222 | -0.409 | 0.0000 |
| Q9WV92 | E41L3 | RcitSRcitGQVLFDK | -0.866 | 0.1583 | -1.058 | 0.0884 | -0.474 | 0.1372 | -0.606 | 0.0059 |
| P09542 | MYL3 | EGNdeamGTVMGAELRcitHVLATLGERLTEDEVEK | -1.024 | 0.1352 | -1.583 | 0.0832 | -0.236 | 0.7834 | -0.619 | 0.0000 |
| Q03265 | ATPA | RTGAIVDVPVGEELLGRcitVVDALGNAIDGK | -1.228 | 0.3162 | 0.760 | 0.6033 | -0.207 | 0.8075 | -0.364 | 0.0000 |
Upregulated proteins are marked in red, and downregulated proteins are marked in blue. Rcit indicates a citrullinated residue, Ndeam indicates a deamidated residue, and Mox indicates an oxidated residue.