Table 1.
Parameters related to the core target network
| Gene | Protein name | Freedom | Closeness Centrality | Betweenness Centrality |
|---|---|---|---|---|
| STAT3 | RAC-alpha serine/threonine-protein kinase | 45 | 0.48 | 0.09 |
| MAPK3 | Mitogen-activated protein kinase | 43 | 0.50 | 0.07 |
| MAPK1 | Mitogen-activated protein kinase 1 | 41 | 0.49 | 0.06 |
| JUN | Transcription factor AP-1 | 41 | 0.47 | 0.05 |
| TP53 | Cellular tumor antigen p53 | 41 | 0.47 | 0.10 |
| AKT1 | RAC-alpha serine/threonine-protein kinase | 38 | 0.48 | 0.08 |
| RELA | Transcription factor p65 | 38 | 0.47 | 0.04 |
| HSP90AA1 | Heat Shock Protein 90 Alpha Family Class A Member 1 | 36 | 0.47 | 0.06 |
| TNF | Tumor necrosis factor | 32 | 0.45 | 0.04 |
| MAPK14 | Mitogen-activated protein kinase 14 | 32 | 0.46 | 0.06 |
| ESR1 | Estrogen receptor | 31 | 0.46 | 0.06 |
| IL6 | Interleukin 6 | 28 | 0.42 | 0.02 |
| FOS | Proto-oncogene c-Fos | 28 | 0.44 | 0.03 |
| EGFR | Epidermal growth factor receptor | 26 | 0.45 | 0.04 |
| MYC | Myc proto-oncogene protein | 24 | 0.45 | 0.02 |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit | 23 | 0.43 | 0.02 |
| STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 22 | 0.43 | 0.01 |
| MAPK8 | Mitogen-activated protein kinase 8 | 22 | 0.41 | 0.03 |
| HIF1A | Hypoxia-inducible factor 1-alpha | 21 | 0.43 | 0.01 |
| NR3C1 | Glucocorticoid receptor | 21 | 0.44 | 0.02 |