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. 2023 Jul 25;14:1214408. doi: 10.3389/fneur.2023.1214408

Figure 2.

Figure 2

Auditory function in fB deficient mice. Auditory Brainstem Response (ABR) was measured in adult WT and fB−/− mice. (A,B) ABR thresholds in 1.5-month (A), and 4-month-old (B) fB−/− mice (red line) and age-matched WT mice (black line). LMER model of the ABR threshold indicated significant effects between WT and fB−/− mice (see Results section). Post-hoc pairwise comparisons were conducted to compare genotypes for each frequency at each age, and significant differences between genotypes are denoted in (A,B) with asterisks (*p < 0.05, **p < 0.01, ***p < 0.001). (C) Average and individual wave I amplitudes for 1.5-month fB−/− and WT mice (randomized subset taken from mice tested in A) in response to 8, 11.3, and 16 kHz stimulus. LMER models of ABR wave I amplitude showed a significant main effect of genotype and stimulus sound pressure level at 8 kHz, 11.3 kHz, and 16 kHz (see Results section). Post-hoc pairwise comparisons were conducted to compare amplitudes across genotypes for each sound level, and significant differences between genotypes are denoted with asterisks (*p < 0.05, **p < 0.01, ***p < 0.001). (D) Average and individual wave I latencies for 1.5-month fB−/− and WT mice (randomized subset taken from mice tested in A) in response to 8, 11.3, and 16 kHz stimulus. LMER models of ABR wave I latency revealed a significant main effect of genotype and stimulus sound pressure level (see Results section) for 8, 11.3, and 16 kHz. Post-hoc pairwise comparisons were conducted to compare latencies across genotypes for each sound level, and significant differences between genotypes are denoted with asterisks (*p < 0.05, **p < 0.01, ***p < 0.001). Error bars in (A,B) represent SEM. “V” in (A,B) indicates that most fB−/− mice showed no response at the examined frequencies.