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. 2023 Jul 25;14:1214408. doi: 10.3389/fneur.2023.1214408

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Copyright © 2023 Brown, Barth, Jafri, Rumschlag, Jenkins, Atkinson and Lang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression changes in the auditory nerve of fB^−/− mice. (A) Heatmap representation of genes differentially expressed between fB^−/− and WT mice. Comparison of auditory nerve tissue from young adult (aged 1.5–2.5 months) fB^−/− and WT control animals found that 706 genes were significantly differentially expressed (p-adj <0.05 and absolute fold change >1.5), with 501 being upregulated and 205 being downregulated. (B,C) Read count representation of neural crest genes (Shank3, Foxm1, Cntf, Notch1, Notch 2, Notch 3, Trio, and Sox4) and myelin-associated genes (Pmp22, Mal, and St3gal1) identified as differentially expressed.