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. 2023 Jul 25;14:1214408. doi: 10.3389/fneur.2023.1214408

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Copyright © 2023 Brown, Barth, Jafri, Rumschlag, Jenkins, Atkinson and Lang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The organ of Corti histology is comparable in fB^−/− and WT mice. (A,B) Light microscopy of toluidine blue-stained 1-month WT and fB^−/− cochlear samples. Representative images of the organ of Corti of WT (A) and fB^−/− (B) mice. TM, tectorial membrane; OSL, osseous spiral lamina; OHC, outer hair cell; IHC, inner hair cell. Images in (A,B) were representative images taken from the middle portion of mouse cochleas. Two mice per group were observed. (C–F) Normal ultra-structures of OHCs and IHCs in young adult fB^−/− cochleas. An efferent (e) terminal connects with an afferent terminal (a) underneath of an inner hair cell. (G,H) Confocal microscopy of MyosinVIIa⁺ hair cells in WT (G) and fB^−/− (H) cochleae. Hair cells are well preserved in both mouse strains.