Table 1.
Selected actin and actin-associated proteins in stereocilia.
| Protein | Gene | Human deafness |
|---|---|---|
| Beta cytoplasmic actin | ACTB | |
| Gamma cytoplasmic actin | ACTG1 | DFNA20/26 |
| Espin | ESPN | DFNB36 |
| Fascin 2 | FSCN2 | |
| Plastin-1 | PLS1 | |
| Xin-actin binding repeat containing 2 | XIRP2 | |
| Whirlin | WHRN | DFNB31 |
| Epidermal growth factor receptor pathway substrate 8 | EPS8 | DFNB36 |
| EPS8-like 2 | EPS8L2 | |
| G-protein signaling modulator 2 | GPSM2 | DFNB82 |
| G-protein subunit alpha i3 | GNAI3 | |
| Unconventional myosin 3 | MYO3A, MYO3B | DFNB30 |
| Unconventional myosin 6 | MYO6 | DFNA22, DFNB37 |
| Unconventional myosin 7 | MYO7A | DFNA11DFNB2USH1B |
| Unconventional myosin 15 | MYO15A | DFNB3 |
| Harmonin | USH1C | DFNB18, USH1C |
| Sans | USH1G | USH1G |
| Calcium + integrin binding family member 2 | CIB2 | DFNB48 |
| BAI1-associated protein 2-like 2 | BAIAP2L2 | |
| Twinfilin-2 | TWF2 | |
| Actin capping protein β2 | CAPZB2 | |
| Destrin (actin depolymerization factor) | DSTN | |
| Cofilin 1 | CFL1 | |
| TRIO and F-actin binding protein | TRIOBP | DFNB28 |
| Ankyrin repeat domain 24 | ANKRD24 | |
| Pejvakin | PJVK | DFNB59 |
| Taperin | TPRN | DFNB79 |