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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Cancer Lett. 2023 Jun 24;568:216284. doi: 10.1016/j.canlet.2023.216284

Table 1.

Top Drug Combinations Inhibiting MM Cells Based on Huber Robust Regression

r2 Compound
1 Target
Gene		 Compound 1 Name Compound 2 Name Compound
2 Target
Gene		 Cmpd
1
Count		 Cmpd
2
Count
0.836 ITK NCGC00344999-01 = ITK(1) VER-82576 HSP90AB1 39 33
0.822 HSP90AB1 Ganetespib BS-194 CDK1 35 46
0.804 HSP90AB1 SNX-5422 NCGC00344999-01 = ITK(1) ITK 35 39
0.765 HSP90AB1 SNX-5422 NCGC00188382-01 = ITK(2) ITK 35 45
0.732 HDAC1 Romidepsin SR-3306 MAPK8 45 46
0.714 TUBB XRP-44X BMS-3 LIMK1 28 37
0.702 HSP90AB1 SNX-5422 NCGC00344990-01 = ITK(3) ITK 35 38
0.678 TUBB XRP-44X ON-01910 PLK1 28 37
0.671 IKBKB IMD-0354 Niclosamide STAT3 45 41
0.658 HSP90AB1 Ganetespib Dacinostat HDAC1 35 44
0.655 AURKA Alisertib Doxorubicin TOP2A 29 46
0.645 PIM3 GDC-0349 PP242 MTOR 34 34
0.644 TLR7 CPG-52364 Sepantronium bromide BIRC5 44 36
0.643 ITK NCGC00344990-01 = ITK(3) VER-82576 HSP90AB1 38 33
0.634 HSP90AB1 AT-13387AU NCGC00344990-01 = ITK(3) ITK 39 38
0.634 CDK1 BS-194 Dacinostat HDAC1 46 44
0.626 MAPK8 TCS JNK 5a Indibulin TUBB 33 28
0.616 CDK1 7-Hydroxystaurosporine PIK-75 PIK3CA 37 33
0.614 ITK NCGC00188382-01 = ITK(2) Methylrosaniline chloride TNFRSF1A 45 36
0.611 PIK3CA PIK-75 Flavopiridol CDK1 33 44
0.606 TUBB XRP-44X IVX-214 PLK1 28 30
0.602 TUBB 4-Demethylepipodophyllotoxin Picropodophyllin IGF1R 40 38
0.602 MET Tivantinib 4-Demethylepipodophyllotoxin TUBB 28 40
0.597 TUBB XRP-44X Picropodophyllin IGF1R 28 38
0.594 MAPK8 SR-3306 Pracinostat HDAC1 46 34
0.583 PLK1 IVX-214 Noscapine TUBB 30 36
0.571 CDK1 BS-194 VER-82576 HSP90AB1 46 33
0.563 TUBB Lexibulin hydrochloride ON-01910 PLK1 27 37
0.557 HSP90AB1 SNX-5422 Methylrosaniline chloride TNFRSF1A 35 36
0.556 TUBB XRP-44X AST-1306 ERBB2 28 28
0.540 HSP90AB1 Geldanamycin Idarubicin hydrochloride TOP2A 34 41
0.540 HSP90AB1 CNF-2024 Idarubicin hydrochloride TOP2A 35 41
0.536 TUBB XRP-44X Tivantinib MET 28 28
0.535 MCL1 VU0482089-2 AV-412 EGFR 29 33
0.534 HSP90AB1 CNF-2024 Doxorubicin TOP2A 35 45
0.531 MCL1 VU0482089-2 1-alpha-Hydroxyergocalciferol VDR 29 28
0.524 PIM3 GDC-0349 GNE-493 PIK3CA 34 40
0.524 IGF1R Picropodophyllin Noscapine TUBB 38 36
0.521 CDK1 R-547 PIK-75 PIK3CA 29 33
0.516 HDAC1 Abexinostat 3-Methyladenine PIK3CA 43 47
0.515 MAPK8 TCS JNK 5a Noscapine TUBB 33 36
0.508 SRC KX-01 Indibulin TUBB 38 28
0.504 TUBB Lexibulin hydrochloride Merck-22-6 AKT1 27 25