Table 2.
Combinations Reducing MYC (n = 10) and Increasing p16 (n = 6) Protein Expression in L363 MM Cells
| Reduced MYC Protein Expression vs. Single Agent/Control in L363 MM Cells | |||||
|---|---|---|---|---|---|
| Drug 1 | Primary Target 1 | Drug 2 | Primary Target 2 | r2 (Robust Regr.) |
†p16 vs. Ctrl |
| BS-194 | CDK1 | Dacinostat | HDAC1 | 0.634 | ✓ |
| Alisertib | AURKA | Doxorubicin | TOP2A | 0.655 | ✓ |
| Geldanamycin | HSP90 | Idarubicin HCl | TOP2A | 0.540 | ✓ |
| Noscapine | TUBB | IVX-214 | PLK1 | 0.583 | ✓ |
| XRP-44X | TUBB | IVX-214 | PLK1 | 0.606 | ✓ |
| BS-194 | CDK1 | VER-82576 | HSP90 | 0.571 | ✓ |
| AT13387AU | HSP90 | ITK(3) | ITK | 0.634 | x |
| SNX-5422 | HSP90 | ITK(3) | ITK | 0.702 | x |
| VER-82576 | HSP90 | ITK(1) | ITK | 0.836 | x |
| VU-482089 | MCL1 | AV-412 | EGFR | 0.535 | x |