表 4. Comparison of hormone and oxidative stress levels between different genotypes of ACE I/D polymorphism subgroups .
ACE I/D多态性不同基因型亚组间激素和氧化应激水平的比较
| Index | Controls | PCOS patients | |||||||
| Total (n=825) | II (n=229) | ID (n=241) | DD (n=57) | Total (n=1 020) | II (n=274) | ID (n=298) | DD (n=95) | ||
| FAI: Free androgen index; FSH: Follicle-stimulating hormone; LH: Luteinizing hormone; MDA: Malondialdehyde; OSI: Oxidative stress index; SHBG: Sex hormone-binding globulin; T-AOC: Total antioxidant capacity; TOS: Total oxidant status; TT: Total testosterone. Comparisons of all parameters were corrected for differences in age and BMI between the two subgroups. * P<0.05, vs. the II genotype subgroup in controls; △P<0.05, vs. the ID genotype subgroup in PCOS patients; §P<0.05, vs. the II genotype subgroup in PCOS patients; #P<0.05, vs. total controls. | |||||||||
| Hormonal levels | |||||||||
| TT/(nmol/L) | 1.47±0.52 | 1.49±0.50 | 1.47±0.53 | 1.41±0.51 | 2.34±0.77# | 2.34±0.73 | 2.35±0.82 | 2.31±0.73 | |
| SHBG/(nmol/L) | 55.06±27.26 | 58.62±28.23 | 51.84±24.89 | 55.70±31.94 | 33.49±19.26# | 34.97±18.63 | 33.28±20.37 | 29.82±16.98△ | |
| FAI | 3.26±2.07 | 3.08±1.99 | 3.42±2.07 | 3.26±2.36 | 9.76±7.03# | 8.94±6.39 | 10.20±7.36 | 10.73±7.56 | |
| LH/FSH | 1.18±1.30 | 1.21±0.98 | 1.15±1.29 | 1.19±0.94 | 2.26±1.23# | 2.38±1.26 | 2.12±1.18§ | 2.34±1.25 | |
| Oxidative stress parameters | |||||||||
| TOS/(nmol H2O2 Equiv./mL) | 11.48±5.38 | 12.01±5.35 | 11.26±5.69 | 10.20±3.83* | 15.13±10.58# | 15.40±11.67 | 14.61±8.94 | 15.95±11.93 | |
| T-AOC/(U/mL/min) | 14.51±2.67 | 14.64±2.48 | 14.48±2.71 | 14.16±3.18 | 15.77±3.09# | 15.80±3.11 | 15.78±3.07 | 15.64±3.10 | |
| OSI | 0.80±0.41 | 0.82±0.39 | 0.79±0.45 | 0.73±0.29 | 0.99±0.79# | 0.99±0.79 | 0.97±0.78 | 1.04±0.81 | |
| MDA/(nmol/mL) | 3.70±1.09 | 3.79±1.08 | 3.66±1.12 | 3.51±1.02 | 4.37±1.32# | 4.25±1.32 | 4.42±1.32 | 4.55±1.29§ | |