表 4. Multivariate Cox regression of recurrence-free survival in the NMIBC cohort and BCG group.
NMIBC队列与BCG亚组无复发生存的多因素Cox分析
| Clinicopathological variable | Total patients (n=93) | BCG group (n=72) | |||
| P | Hazard ratio (95%CI) | P | Hazard ratio (95%CI) | ||
| CI: Confidence interval. NMIBC, BCG, EPI, recurrent≤1 rec/year, recurrent>1 rec/year: Note the same as table 1. | |||||
| Gender (female) | |||||
| Male | 0.275 | 0.409 (0.082−2.035) | 0.688 | 0.689 (0.121−4.044) | |
| Age (≤60 yr.) | |||||
| 60−70 yr. | 0.916 | 1.061 (0.353−3.191) | 0.860 | 1.145 (0.254−5.164) | |
| >70 yr. | 0.945 | 1.060 (0.207−5.438) | 0.812 | 0.786 (0.107−5.754) | |
| Smoking history (no) | |||||
| Yes | 0.355 | 1.536 (0.618−3.817) | 0.700 | 1.339 (0.303−5.923) | |
| Prior recurrence rate (primary) | |||||
| Recurrent≤1 rec/year | 0.036 | 3.863 (1.095−13.636) | 0.087 | 6.876 (0.754−62.671) | |
| Recurrent>1 rec/year | 0.001 | 13.347 (4.645−38.356) | 0.001 | 53.506 (6.452−443.698) | |
| T stage (Ta) | |||||
| T1 | 0.648 | 1.337 (0.384−4.649) | 0.484 | 1.570 (0.444−5.548) | |
| Grade (low grade) | |||||
| High grade | 0.230 | 1.787 (0.692−4.613) | 0.256 | 2.099 (0.584−7.547) | |
| Tumor size (<3 cm) | |||||
| ≥3 cm | 0.435 | 1.642 (0.478−5.572) | 0.046 | 4.998 (1.027−24.333) | |
| Amount of tumors (≤3) | |||||
| >3 | 0.402 | 1.520 (0.517−4.051) | 0.777 | 0.793 (0.159−3.956) | |
| Treatment group (BCG) | |||||
| EPI | 0.020 | 2.851 (1.182−6.881) | − | − | |