表 1. The results of prenatal a-CGH in 3 677 gravidas with advanced maternal age.
3 677例高龄孕妇羊水a-CGH检测结果
| Age/yr. | n | a-CGH results/case (%) | |||
| Aneuploidies | p/lpCNVs* | VUS | Normal | ||
| p/lpCNVs: Pathogenic or likely pathogenic copy number variations; VUS: Uncertain clinical significance. * Diagnostic CNVs means p/lpCNVs. | |||||
| ≥35 | 850 | 3 (0.35) | 8 (0.94) | 6 (0.71) | 833 (98.00) |
| 36- | 783 | 7 (0.89) | 11 (1.40) | 9 (1.15) | 756 (96.55) |
| 37- | 768 | 5 (0.65) | 9 (1.17) | 5 (0.65) | 749 (97.53) |
| 38- | 381 | 4 (1.05) | 1 (0.26) | 2 (0.52) | 374 (98.16) |
| 39- | 279 | 3 (1.08) | 1 (0.36) | 3 (1.08) | 272 (97.49) |
| 40- | 227 | 3 (1.32) | 2 (0.88) | 2 (0.88) | 220 (96.92) |
| >40 | 389 | 15 (3.86) | 3 (0.77) | 4 (1.03) | 367 (94.34) |
| Total | 3 677 | 40 (1.09) | 35 (0.95) | 31 (0.84) | 3 571 (97.12) |